"What causes cancer?"
2/26/00: This question was asked
in the alt.support.cancer.breast newsgroup. We are fortunate
that we have the Chief of breast surgery from Johns Hopkins drop in and help
us out, virtually, every day. This physician gave the most thorough,
easily understood answer I could imagine. It must be remembered,
that this answer is exactly why we need to support genetic research, as
well as pathology, and immunology. Why? Because our bodies do respond
to changes, and threats to its homeostasis (look at my glossary page).
This is the reason I kept questioning why the protocol for treatment was
"three positive nodes." Three out of what? I was told every
woman has a different number of nodes. Ok, I'll accept that, but
there's a reason why, in my opinion.
The immune system responds to
any threat against the body. Just look at a cut on your finger.
The tissue becomes somewhat inflamed (red), and there's a whitish environment
around it (like blood isn't there). The lymphocytes and phagocytes
move in to protect your...even your little finger.
So, here is what this kind friend of ours said,
last night, when we know he was tired (and believe me we don't always agree
in the newsgroup with him, but we're grateful!). Here was his challenger:
Vicki wrote in message news:
Here is a big question...."Have any of you ever been told the WHY?"
Why do you have cancer? What is/was the initial cause?
If you can believe it there IS the technology available to find the answers!
"There are two levels at which this question could
be answered.
1. All cancer is to a major extent the "erasure"
of the DNA encoded message that tells a cell to live for so many generations
and then to die. In other words we all come with a built in self-destruct
sequence in our DNA. What exactly causes this "erasure" is still hotly
debated and the reason is probably different in different kinds of tumors
and different in different individuals. It is clear that some accumulation
of genetic hits through life ( including any you might have inherited)
increase the probability that this "erasure" occurs.
2. Why yours specifically is harder-- the best
models of colon cancer for instance suggest that it takes a number of hits
occurring over many years to finally complete the "erasure" and let the
cells grow un-checked. The cancer cells grow in a very selfish way - eating
all they can get and where possible denying nourishment to the normal surrounding
tissue. Since cancer cells are then basically immortal if they continue
to be fed, they just continue to wreck havoc in their search for better
living conditions and more "luxurious" quarters. You just had a very unlucky
series of exposures and or inherited genes that predisposed you more than
others your same age.
Take heart though - many cancer researchers think
that if anyone lives long enough cancer will eventually get you.
William Dooley, MD, FACS
Director , The Johns Hopkins Breast Center
Thank you, Dr.
Dooley! We appreciate
you, very much! - Dr.
Dooley is now Chairman, Board of Trustee,
PROJECT!
OUTREACH and Chair, Surgical Oncology,
University of Oklahoma, Health Sciences Center, and has been as Vice Chair of
"The PROJECT!'s Scientific Affairs, began the effort to hold no cost breast
screening seminars for large groups of the public, through collaboration with
breast cancer groups. The women examined were given coupons for free mammograms,
and followed up by physicians, at all times regardless of income.

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Sunday, June 26, 2005